Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata

Alban Pereira; Eduardo Vottero; Michel Roberge; A Grant Mauk; Raymond J Andersen

doi:10.1021/np060111x

Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata

J Nat Prod. 2006 Oct;69(10):1496-9. doi: 10.1021/np060111x.

Authors

Alban Pereira¹, Eduardo Vottero, Michel Roberge, A Grant Mauk, Raymond J Andersen

Affiliation

¹ Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z1.

PMID: 17067170
DOI: 10.1021/np060111x

Abstract

Crude extracts of the marine hydroid Garveia annulata show potent inhibition of indoleamine 2,3-dioxygenase (IDO). Fractionation of the extract led to the identification of the new polyketides annulin C (1), 2-hydroxygarveatin E (4), garveatin E (5), and garvin C (9). Annulins A (2), B (3), and C (1) were found to be submicromolar inhibitors of IDO.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Hydrozoa / chemistry*
Indoleamine-Pyrrole 2,3,-Dioxygenase / antagonists & inhibitors*
Macrolides* / chemistry
Macrolides* / isolation & purification
Macrolides* / pharmacokinetics
Macrolides* / pharmacology
Marine Biology
Molecular Structure
Naphthoquinones* / chemistry
Naphthoquinones* / isolation & purification
Naphthoquinones* / pharmacokinetics
Naphthoquinones* / pharmacology
Pyrones* / chemistry
Pyrones* / isolation & purification
Pyrones* / pharmacokinetics
Pyrones* / pharmacology

Substances

Indoleamine-Pyrrole 2,3,-Dioxygenase
Macrolides
Naphthoquinones
Pyrones
annulin B